Table 1.
Clinical and echocardiographic parameters by heart failure classification
| Variable | All | NYHA HF Class I (N=18) |
NYHA HF Class II-IV (N=24) |
p-value (I vs. II-IV) |
|---|---|---|---|---|
| Heart rate (beats per minute) | 81±20 | 80±24 | 81±16 | 0.9 |
| Systolic blood pressure (mm Hg) | 122±23 | 126±28 | 119±18 | 0.7 |
| Chemotherapy (N/%) | 38 (90) | 16 (89) | 22 (92) | 1 |
| Stem cell transplant (N/%) | 13 (31) | 10 (56) | 2 (8) | 0.001 |
| Left ventricular ejection fraction (%) | 57±13 | 59±12 | 56±13 | 0.4 |
| Mitral annular peak systolic velocity (cm/s) | 8.8±3.6 | 9.8±3.1 | 8.2±3.9 | 0.056 |
| Anteroseptal thickness (cm) | 1.6±0.4 | 1.5±0.4 | 1.6±0.3 | 0.1 |
| Inferolateral thickness (cm) | 1.5±0.3 | 1.3±0.3 | 1.6±0.4 | 0.047 |
| Left ventricular mass index (g/m2) | 119±50 | 107±56 | 127±44 | 0.049 |
| Left atrial volume index (mL/m2) | 34±11 | 30±10 | 37±10 | 0.03 |
| E/A ratio* | 1.3±0.6 | 1±0.4 | 1.6±0.7 | 0.02 |
| E’ (cm/s) | 7±3 | 8.6±3 | 5.8±3 | 0.006 |
| E/E’ | 18±15 | 15±14 | 20±15 | 0.05 |
| Deceleration time (ms) | 216±76 | 246±88 | 194±59 | 0.03 |
| Left ventricular ejection time (ms) | 266±49 | 282±42 | 254±51 | 0.07 |
| Ejection time/cycle length | 0.35±0.09 | 0.37±0.08 | 0.33±0.1 | 0.2 |
| Preejection period (ms) | 61±27 | 68±24 | 56±29 | 0.1 |
| Preejection period/ejection time | 0.24±0.12 | 0.22±0.1 | 0.23±0.1 | 0.6 |
| Creatinine (mg/dL) | 1.6±1.1 | 1.3±0.7 | 1.8±1.3 | 0.2 |
| Alkaline phosphatase (IU/L) | 133±134 | 83±25 | 171±168 | 0.1 |
| Aspartate aminotransferase (IU/L) | 41±67 | 27±15 | 51±88 | 0.4 |
| Alanine aminotransferase (IU/L) | 39±61 | 30±20 | 45±80 | 0.9 |
*
4 patients with atrial fibrillation did not have E/A data