Table 3.

Univariate and multivariable analysis of predictors of mortality

Variable	χ2	Hazard Ratio (95% C.I.)	p-value
NYHA Heart Failure Class (1 df, linear)	12.8	1.89 (1.33-2.68)	<0.001
NYHA Heart Failure Class (1 df, binary II, III, IV vs. I)*	10.2	5.31 (1.91-14.8)	0.001
Left ventricular ejection time	9.2	0.985 (0.975-0.995)	0.002
Left ventricular ejection time (by 10 ms change)*	9.2	0.857 (0.78-0.95)	0.002
Alkaline phosphatase	16.5	1.006 (1.003-1.009)	<0.001
Alkaline phosphatase (by 10 IU change)*	16.5	1.059 (1.03-1.09)	<0.001
Aspartate aminotransferase*	8.96	1.008 (1.003-1.014)	0.003
Alanine aminotransferase*	8.4	1.009 (1.003-1.015)	0.004
Left atrial volume index*	3.4	1.04 (1.0-1.08)	0.07
Male gender*	3.4	2.4 (0.94-6.2)	0.07
Systolic blood pressure*	3.0	0.98 (0.96-1.0)	0.08
Deceleration time*	2.7	0.995 (0.99-1.0)	0.1
Anteroseptal thickness	2.2	2.2 (0.78-6.1)	0.14
E/E’	1.9	1.0 (0.99-1.04)	0.17
Inferolateral thickness	1.8	2.2 (0.68-7.4)	0.18
E/A ratio	1.8	1.61 (0.8-3.3)	0.18
Heart rate	1.0	1.0 (0.99-1.03)	0.3
Lateral E’	0.89	0.94 (0.82-1.07)	0.34
Left ventricular mass index	0.5	1 (0.996-1.0009)	0.5
Left ventricular ejection fraction	0.4	0.99 (0.96-1.02)	0.5
Preejection period/ET	0.2	0.5 (0.01-17.7)	0.7
Age	0.1	1.0 (0.97-1.04)	0.7
Creatinine	0.1	1.07 (0.7-1.6)	0.7
Mitral annular peak systolic velocity	0.1	0.98 (0.87-1.1)	0.7
ET/cycle length	0.01	0.8 (0.008-72)	0.9
Multivariable model
NYHA Heart Failure Class (binary, II,III,IV versus I)	7.7	4.9 (1.58-14.9)	0.006
Left ventricular ejection time (by 10 ms change)	6.5	0.87 (0.775-0.967)	0.01
Alkaline phosphatase (by 10 IU change)	6.0	1.036 (1.007-1.065)	0.01

^*variables included in multivariable model; NYHA-New York Heart Association; E’ mitral annular velocity; E/E’ ratio of mitral inflow to mitral annular velocity