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. Author manuscript; available in PMC: 2010 Mar 11.
Published in final edited form as: J Am Chem Soc. 2009 Mar 11;131(9):3136–3137. doi: 10.1021/ja808217s

Figure 2.

Figure 2

J1/2 mutations affect P1 dynamics in the open state. Shown on the left are measured (black) and simulated (dotted red) spectra for the SOSL substrate bound to the -3A, wild type, and +5A ribozymes. The data revealed a decrease of motional restriction as J1/2 is extended. This is depicted by the schematic renditions shown on the right.