Fig. 2.
Representative isothermal titration calorimetry measurements and fit: n-phenylglycinonitrile titration (stock concentration 1.4mM) into L99A/M102Q (initial concentration 42.5μM). An initial injection of 2μL was followed by 29 ×10μL injections of ligand to a final ligand concentration in the reaction cell of 237.9μM.