Table 1.
Occurrence of anti-Hu reactivity in mice.
| Genotype | Total # of mice | # of mice with SCLC tumors | # of mice with positive anti-Hu reactivity (%)* | # of mice with positive anti-Hu reactivity above background (%)** | Lesion latency (days) |
|---|---|---|---|---|---|
|
Wildtype FVB |
41 | NA | 4 (10) | 0 (0) | NA |
|
SCLC-prone LucR;P53F;RbF |
71 | 55a | 19b (27) | 10c (14) | 141–520 |
*
Positive Western Blot signal at 1:250 dilution of plasma or serum
**
Positive Western Blot signal at fold dilution > 1:5000 of plasma or serum
a
Sixteen mice had no SCLC lesions: fourteen mice were arbitrarily sacrificed for experimental purposes before SCLC became apparent; one mouse spontaneously died; one mouse showing obvious discomfort was euthanized eleven months post Adeno-Cre infection.
b
Includes four mice without SCLC lesions (three arbitrarily sacrificed and one sick)
c
Includes two mice without SCLC lesions (one arbitrarily sacrificed and one sick)
NA= not applicable