TABLE 1.

IC₅₀ values of imide and lactam half-sandwich complexes 1–3 and (R_Ru)-21 against Pim1, GSK3β, TrkA, and CLK2.^a

	Pim1	GSK3β	TrkA	CLK2
(RRu)-3	0.7	1.0	65	b
(SRu)-3	0.2	15	40	b
(RRu)-1	80	330	20	c
(SRu)-1	40	1000	50	c
(RRu)-2	25	1000	75	30
(SRu)-2	6	370	15	5
(RRu)-21	390	1200	6	d

^aIC₅₀ data were obtained by phosphorylation of substrate peptides with [γ-³²P]ATP or [γ-³³P]ATP and 100 μM ATP in the presence different concentrations of organometallic kinase inhibitors. Each IC₅₀ value was determined from at least two independent measurements and the average was taken. See experimental section for more details.

^bRacemic 3: IC₅₀ = 35 nM at 100 μM ATP.

^cRacemic 1: 26% CLK2 activity at 100 nM 1 and 10 μM ATP.

^d50% CLK2 activity at 100 nM of (R_Ru)-21 at 10 μM ATP.