Table 1.
Zebrafish G protein γ subunit genes
| Subunit | Accession # | Chromosome | CaaX Motif |
Homology to Human Gamma Subunits |
|
|---|---|---|---|---|---|
| Nucleotide | Protein | % Identity / % Similarity | |||
| gngt1† | NM_199967 | NP_956261 | 19 | *CVIC | 66.7 / 81.3 |
| gngt2a | BC059612 | Q6PBR4 | 3 | *CIIT | 70.0 / 88.6 |
| gngt2b | none | none | 12 | *CIIT | 1 54.3 / 78.6 |
| gng2‡ | DQ109815 | Q15KE4 | 13 | CAIL | 94.4 / 98.6 |
| gng3§ | NM_131841 | NP_571916 | 21 | CALL | 93.4 / 98.7 |
| gng4 | XM_001335940 | XP_001335976 | 13 | CTIL | 88.2 / 100 |
| gng5 | - | NP_999886 | 2 | CSFL | 84.1 / 92.8 |
| gng7 | - | NP_001002397 | 2 | CIIL | 94.2 / 98.6 |
| gng8 | zgc:110316 | Q503Q6 | 21 | CTVL | 80.3 / 97.2 |
| gng10 | XM_001923181 | XP_001923216 | 5 | CTLL | 76.8 / 92.8 |
| gng12a | NM_213312 | NP_998477 | 2 | CTIL | 76.7 / 89.0 |
| gng12b | none | none | 6 | CTIL | 78.1 / 87.7 |
| gng13 | XM_001333427 | XP_001333463 | 3 | CVLL | 75.0 / 91.2 |
| gng14 | XM_001338349 | XP_001338385 | 1 | CVIL | 2 55.9 / 73.5 |
| gng15 | XM_681703 | XP_686795 | 6 | CVLL | 3 54.9 / 78.1 |
| gng16 | none | none | 1 | CGLL | 4 56.2 / 69.9 |
| gng17 | none | none | 3 | CVLL | 4 49.3 / 70.4 |
The identified zebrafish Gγ subunit genes, their associated sequences, chromosomal location and CaaX motif. The zebrafish Gγ subunits that lack an obvious human ortholog are compared to the human subunit that has the highest homology
1
gngt2b was compared to GNGT2
2
gng14 was compared to GNG13
3
gng15 was compared to GNG7
4
gng16 was compared to GNG5
5
gng17 was compared to GNG10.
*
= CaaX motifs that are preferred by farnesyl transferase over geranylgeranyl transferase.
†
Previously identified zebrafish subunits: Chen et al., 2007