Table III.
Distribution of Genotypes at the Tag SNP Sites in STAT3 and TYK2 Between CD Patients and Control Subjects
| Gene | SNP | Genotype | Number (%) of genotypes in | Genotype comparisona | ||
|---|---|---|---|---|---|---|
| CD | Control | OR (95% CI) | P value | |||
| STAT3 | rs8074524 | C/C | 34 (41.0) | 75 (37.5) | 1.156 (0.686–1.951) | 0.586 |
| C/T | 38 (45.8) | 103 (51.5) | 0.795 (0.476–1.329) | 0.382 | ||
| T/T | 11 (13.3) | 22 (11.0) | 1.236 (0.570–2.680) | 0.591 | ||
| rs2293152 | G/G | 27 (32.5) | 84 (42.0) | 0.666 (0.389–1.141) | 0.139 | |
| G/C | 37 (44.6) | 99 (49.5) | 0.821 (0.491–1.372) | 0.451 | ||
| C/C | 19 (22.9) | 17 (8.5) | 3.196 (1.566–6.523) | 0.001 | ||
| rs957970 | A/A | 19 (22.9) | 55 (27.5) | 0.783 (0.430–1.424) | 0.423 | |
| G/A | 46 (55.4) | 108 (54.0) | 1.059 (0.633–1.772) | 0.827 | ||
| G/G | 18 (21.7) | 37 (18.5) | 1.220 (0.648–2.296) | 0.538 | ||
| TYK2 | rs280496 | C/C | 61 (73.5) | 162 (81.0) | 0.650 (0.356–1.187) | 0.161 |
| C/G | 22 (26.5) | 38 (19.0) | 1.538 (0.842–2.807) | 0.161 | ||
| G/G | 0 | 0 | – | – | ||
| rs280519 | A/A | 37 (44.6) | 63 (31.5) | 1.749 (1.034–2.959) | 0.037 | |
| A/G | 35 (42.2) | 98 (49.0) | 0.759 (0.453–1.272) | 0.295 | ||
| G/G | 11 (13.2) | 39 (19.5) | 0.631 (0.306–1.302) | 0.212 | ||
| rs2304256 | C/C | 52 (62.7) | 86 (43.0) | 2.224 (1.315–3.716) | 0.003 | |
| C/A | 25 (30.1) | 90 (45.0) | 0.527 (0.305–0.909) | 0.021 | ||
| A/A | 6 (7.2) | 24 (12.0) | 0.571 (0.225–1.454) | 0.240 | ||
| rs280523 | G/G | 71 (85.5) | 170 (85.0) | 1.044 (0.506–2.155) | 0.907 | |
| G/A | 12 (14.5) | 30 (15.0) | 0.958 (0.464–1.976) | 0.907 | ||
| A/A | 0 | 0 | – | – | ||
| Total number of subjects | 83 | 200 | ||||
OR odds ratio, CI confidence interval
aEach genotype was compared to other genotypes combined using a logistic regression analysis