Fig. 2.

Histology. a The gross appearance of the epithelioid variant of pleomorphic liposarcoma depicts a portion of the large (22 × 16 × 5 cm), solid, multilobated mass with yellow-orange and pink-white areas. b Hematoxylin and eosin stain: Low magnification shows most of the tumor cells had abundant granular eosinophilic cytoplasm (right upper and lower pink areas), but focal zones of the tumor also had varying amounts of cytoplasmic lipid (central to left pink white area) confirmed with an oil red O stain (not shown). c Hematoxylin and eosin stain: This higher magnification shows the trabecular arrangement of the granular epithelioid tumor cells with distinct cytoplasmic borders separated by capillaries resembling an epithelioid neoplasm. d Hematoxylin and eosin stain: This higher magnification reveals prominent cytoplasmic vacuolation, including signet ring-like lipoblasts (black arrows), but convincing multivacuolated lipoblasts were not identified. e Hematoxylin and eosin stain: Only focal nuclear pleomorphism was present