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. 2009 Dec 8;4(12):e8198. doi: 10.1371/journal.pone.0008198

Figure 1. Chemotaxis of monocytic cells in response to a panel of BMPs.

Figure 1

A: WEHI 274.1 cell migration through transwell chamber filters in response to 10 pg/ml BMP7, BMP2, BMP6 or GDF7 in the lower chamber. For comparison, cells were also stimulated with MCP-1 (100 ng/ml). The chemotaxis index (CI) is shown as mean +/− SEM. MCP-1 (CI = 139+/−45, n = 4); BMP7 (CI = 93+/−38, n = 5); BMP2 (CI = 116+/−40, n = 4); BMP6 (CI = −23+/−6, n = 3); GDF7 (CI = 10+/−10, n = 3). B: Dose response curves for chemotaxis of WEHI 274.1 cells in response to BMP7, BMP6 and GDF7 (n≥3 for each protein at each concentration). Migration in the presence of BMP7 differs significantly from migration in the presence of BMP6 or of GDF7; (*) p<0.05; (**) p<0.01; (***) p<0.002 (Student's t test).