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. Author manuscript; available in PMC: 2010 Jun 1.
Published in final edited form as: Biomaterials. 2009 Sep 19;30(35):6757–6767. doi: 10.1016/j.biomaterials.2009.08.037

Fig. 4. Alginate gels carrying IL-15SA elicit accumulation of CD8+ T-cells in the matrix.

Fig. 4

Established B16-ova tumors were treated on d14 by peritumoral injection of empty alginate gels or gels carrying antigen-pulsed DCs and/or IL-15SA (n = 4–5 per group). Gels were recovered on d28 for analysis. (A) Representative flow cytometry analyses (CD8 vs T cell receptor) of T-cell infiltration in gels. Mean numbers of CD4+ (B) CD8+ (C), and antigen-specific ova tetramer-stained T-cells recovered from gels (D) show increase in the number of CD8+ and antigen-specific T cells at the tumor microenvironment upon addition of IL-15SA. (error bars: s.e.m.)