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. 2009 Dec 14;4(12):e8282. doi: 10.1371/journal.pone.0008282

Figure 7. Hierarchical clustering of ACE haplotypes from different ethnic populations.

Figure 7

A. Most parsimonious hierarchical classification tree for ACE haplotypes of individuals from four different ethnic origins and patient N1 is shown. Cladistic analysis was based on 13 informative polymorphisms and revealed 6 levels of divergence. Detailed description of samples is shown only for first two levels; for higher divergence only number of samples is indicated in parentheses. The size of boxes correlates with number of samples within the clade. Human populations were CEU, Caucasians; JPT, Japan; YRI, Africans; CHB, Chinese; and N1, patient with Trp1197Stop mutation. N1 patient is similar to Nigerians YRI-19211 and YRI-18517, and one Chinese CHB-18577. B. ACE genotypes and haplotypes for patient N1 and individuals from levels 1, 2 and 3 are shown. Positions highlighted in green were conservative in all shown individuals. Polymorphic nucleotides in N1 are highlighted in red, and show in alternative colors (yellow vs. blue) in other clades/individuals. Some positions were C/T or A/G heterozygous; or genotyping data were missing (N/N). SNPs (“rs” with number), position of the I/D polymorphism, and the position of W1197X mutation in N1 are shown on the top of the table. Linkage disequilibrium plot for Nigerian population is presented on the bottom (source: International HapMap project at http://www.hapmap.org).