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A. Clustering of the patient N1 haplotype along clades identified in French [51], British [48] and African-originated [50] populations. B. Detailed haplotypes of identified clades and N1 are presented. N1 carrier of the W1197X mutation perfectly matched with Africa-originated clade I (sub-clades 1, 2, and 7) and was consistently associated with clades represented high ACE plasma level (see text).
