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. 2009 Nov 24;101(11):1817–1823. doi: 10.1038/sj.bjc.6605428

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Copyright © 2009 Cancer Research UK

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The figure shows that having at least one copy of the CYP2C8*3 allele conferred an increased risk for an early breast cancer-related event in tamoxifen-treated women with invasive ER-positive cancers (log rank 4.47; 1 df; P=0.034). HR 9.10 (95% CI 1.39-59.6; P=0.021), adjusted for invasive tumour size, age, PR, histological grade, axillary lymph node status, CYP2C8*4, CYP2C9*2, and CYP2C9*3. The number of patients at each time point is indicated.