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SH-SY5Y cells can be differentiated in culture. Phase-contrast images of SH-SY5Y cells undifferentiated (A and B) and following differentiation for 10 days with retinoic acid (C and D) or 4 days with retinoic acid followed by 6 days with BDNF (E and F). Using either differentiation protocol, the cells extend long neural processes (arrows). Using retinoic acid alone, a few cells do not adopt a neural morphology (arrowheads in C and D). Bar = 100 μm (A, C and E) or 30 μm (B, D and F).
