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. 2009 Sep 4;10(11):1585–1598. doi: 10.1111/j.1600-0854.2009.00972.x

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© 2009 John Wiley & Sons A/S

Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.

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Cajal bodies and gems increase their colocalization on differentiation. A) SH-SY5Y cells grown without (i) or with (ii) RA followed by BDNF. Nuclear gems containing SMN alone (green, arrow in i) and CBs containing coilin alone (red, arrowhead in i) are seen frequently in undifferentiated cells. In differentiated cells, the proportion of nuclear bodies containing both SMN and coilin is increased (arrows in ii). Bar = 10 μm. B) Graph showing the percentage of total nuclear bodies that contain both SMN and coilin before and after differentiation with RA and BDNF (total n = 335 cells, three independent experiments). C) Graph showing the increase in number of colocalized bodies per cell. The change is statistically significant using an unpaired, two-tailed t-test (p < 0.001).