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. 2009 Sep 4;10(11):1585–1598. doi: 10.1111/j.1600-0854.2009.00972.x

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© 2009 John Wiley & Sons A/S

Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.

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Inhibition of protein methylation causes separation of CB and gems. A) Top panel: antibodies to SMN (magenta) and coilin (green) show very little colocalization in undifferentiated or BDNF-differentiated cells treated for 24 h with AdOx or MTA. Very few coilin-containing CBs are seen (arrows). Bottom panel: DAPI (4′-6-Diamidino-2-phenylindole) counterstaining of nuclei. B) The percentage of nuclear bodies containing both SMN and coilin is decreased in cells treated with AdOx or MTA (total n = 657). C) The number of bodies per cell containing both SMN and coilin is decreased in cells treated with AdOx or MTA. D) The average number of coilin-positive foci per cell decreases on inhibition of methylation. Changes between untreated and treated populations are significant using one-way anova with Bonferroni multiple comparison post-test.