Table I.

Amino Acid Residues Identified by Geometric Calculations as Forming GABA-Binding Pockets in the Pentameric Model of the ρ1 GABA_C Receptor

Residue	ω-value	ASA	Residue	ω-value	ASA	Residue	ω-value	ASA
Q83	0.027	0.09	Q16017	0.089	0.21	T21817,37,38	0.025	0.13
E85	0.020	0.20	L16617	0.034	0.28	I22217	0.017	0.45
L87	0.080	0.08	Y16717	0.010	0.07	S22317	0.042	0.27
Y10215,37	0.002	0.03	S16817,37,39	0.005	0.25	L22417	0.006	0.05
R10415,39	0.017	0.08	L16917	0.011	0.04	S22517	0.011	0.05
H10515,39,40	0.005	0.17	R17017,39	0.002	0.08	Q22617	0.005	0.73
M122	0.014	0.24	C177	0.002	0.01	F22717	0.002	0.20
F13817,37	0.004	0.03	S192	0.031	0.21	L238	0.070	0.38
V14017	0.027	0.12	E194	0.002	0.09	F24037	0.089	0.29
H14117,40	0.004	0.22	E196	0.002	0.03	Y24137	0.017	0.56
T152	0.021	0.04	S197	0.007	0.02	S24237,39	0.041	0.65
D153	0.041	0.23	Y19815	0.005	0.20	S24315,39	0.033	0.24
M15617	0.014	0.09	A199	0.006	0.05	T244	0.002	0.90
L15717	0.023	0.02	K21138,40	0.090	0.19	Y247	0.002	0.08
R15817,39	0.002	0.16	N21338	0.080	0.23	R24915,39	0.003	0.02

Accessible solvent area (ASA) of amino acid residues is calculated as a fraction of the extended standard state for a residue in tripeptide Gly-X-Gly.⁴¹