Table II.
Risk of prostate cancer associated with SNPs in the 8q24, 17q12, and 17q24.3 chromosomal regions
| Study I & II* | Study I only† | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variable or SNP | Region | Associated risk group | Frequency of associated factor (%) | OR | 95% CI | P-value‡ | Frequency of associated factor (%) | OR | 95% CI | P-value‡ | ||||
| Cases (n=1308) | Controls (n=1266) | Cases (n=475) | Controls (n=364) | |||||||||||
| Family history | ||||||||||||||
| of PC | Yes | 20.9 | 10.8 | 2.32 | 1.85 | 2.92 | 4.3 × 10−29 | 19.0 | 10.7 | 1.86 | 1.04 | 3.35 | 0.04 | |
| rs4430796 | 17q12 | AA | 32.9 | 25.0 | 1.43 | 1.19 | 1.71 | 9.9 × 10−6 | 31.8 | 26.7 | 1.52 | 0.97 | 2.41 | 0.07 |
| rs1859962 | 17q24.3 | GG | 27.3 | 23.2 | 1.25 | 1.03 | 1.51 | 6.6 × 10−4 | 29.3 | 25.0 | 1.41 | 0.89 | 2.24 | 0.01 |
| rs6983561 | 8q24 | CC+CA | 11.1 | 6.5 | 1.76 | 1.30 | 2.38 | 4.0 × 10−6 | 11.8 | 3.9 | 2.63 | 1.17 | 6.10 | 0.02 |
| rs6983267 | 8q24 | GG+GT | 80.8 | 75.1 | 1.34 | 1.10 | 1.64 | 6.7 × 10−4 | 81.9 | 74.2 | 1.08 | 0.66 | 1.79 | 0.76 |
| rs1447295 | 8q24 | AA+AC | 25.2 | 19.4 | 1.34 | 1.10 | 1.63 | 3.3 × 10−14 | 25.3 | 19.5 | 1.35 | 0.82 | 2.22 | 0.24 |
*
Adjusted for age at reference date; men with missing genotype information for any SNP were excluded from the analysis (n=97 cases, n=58 controls).
†
Two-sided p-values were calculated by comparing the -2 Log Likelihood difference between nested models.
‡
Models were adjusted for serum PSA in addition to age at reference date and included cases and controls from Study I with information for PSA.