Table III.
Population attributable risk percent (PAR%) for SNPs in the 8q24, 17q12, and 17q24.3 chromosomal regions
| Variable or SNP | Associated risk group | Frequency of associated factor (%) | PAR% | Adjusted PAR%* | ||
|---|---|---|---|---|---|---|
| Cases | Controls | 3% Prevalence | 5% Prevalence | |||
| 1st degree family history of PC | Yes | 20.9 | 10.8 | 12.5 | 11.8 | 11.0 |
| rs4430796 | AA | 32.9 | 25.0 | 9.7 | 9.4 | 9.1 |
| rs1859962 | GG | 27.3 | 23.2 | 5.4 | 5.3 | 5.2 |
| rs6983561 | CC+CA | 11.1 | 6.5 | 4.7 | 4.5 | 4.3 |
| rs6983267 | GG+GT | 80.8 | 75.1 | 20.4 | 19.8 | 19.0 |
| rs1447295 | AA+AC | 25.2 | 19.4 | 6.2 | 6.0 | 5.8 |
| All five SNPs | All† | 0.3 | 0.1 | 39.2 | 38.1 | 37.0 |
| All five SNPs and family history | All‡ | 0.1 | 0 | 46.7 | 45.4 | 45.0 |
*
PAR% adjusted for inflation due to estimating relative risk using the odds ratios, at the indicated probability of being diagnosed with prostate cancer.
†
Men with five at-risk genotypes.
‡
Men with five at-risk genotypes plus a positive family history of prostate cancer.