Table IV.

Risk of prostate cancer associated with cumulative effects of SNPs in the 8q24, 17q12, and 17q24.3 chromosomal regions and family history of prostate cancer (PC)

Variable	Cases		Controls		Odds ratio*	95% CI		P-value†,‡
	n=1308	%	n=1266	%
Genotypes at five SNPs §
1st degree family history of PC					2.31	1.84	2.91	9.5 × 10−12
No. of associated genotypes
0	80	6.6	143	11.8	1.00	Reference
1	431	35.6	499	41.3	1.48	1.09	2.01
2	450	37.2	421	34.9	1.88	1.38	2.56
3	206	17.0	122	10.1	2.97	2.08	4.26
≥4	44	3.6	23	1.9	3.36	1.90	6.08	1.2 × 10−12
Genotypes at five SNPs and family history||
No. of associated factors
0	65	5.4	130	10.8	1.00	Reference
1	327	27.0	461	38.2	1.41	1.02	1.97
2	481	39.7	425	35.2	2.25	1.63	3.13
3	258	21.3	150	12.4	3.43	2.40	4.94
4	70	5.8	38	3.2	3.65	2.24	6.03
≥5	10	0.8	4	0.3	4.92	1.58	18.53	1.5 × 10−20

^*Adjusted for age at reference date; men with missing genotype information for any SNP were excluded from the analysis (n=97 cases, n=58 controls).

^†Two-sided p-values were calculated by comparing the −2 Log Likelihood difference between nested models.

^‡P-values for the number of associated genotypes and family history were calculated based on the Cochran-Armitage test for trend.

^§Testing for the cumulative effect of five SNPs (rs4430796, rs1859962, rs6983561, rs6983267, rs1447295), adjusted for age and family history.

^||Testing for the cumulative effect of the five SNPs and family history of prostate cancer, adjusted for age.