. Author manuscript; available in PMC: 2010 Mar 1.

Published in final edited form as: Prostate. 2009 Mar 1;69(4):363–372. doi: 10.1002/pros.20887

Table V.

Prostate cancer-specific mortality associated with SNPs in the 8q24, 17q12 and 17q24.3 chromosomal regions

Variable or SNP (alleles)	Chromosomal region	Associated risk group^*	Frequency of associated SNP or family history (%)		Hazard ratio
			Cases^† (n=1162)	PC-specific deaths (n=45)	HR^‡	95% CI
1^st degree family history of PC		Yes	21.8	11.1	0.29	0.07	1.20
rs4430796 (G,A)	17q12	AA	32.2	40.5	1.34	0.65	2.77
rs1859962 (T,G)	17q24.3	GG	28.0	23.3	0.40	0.15	1.04
rs6983561 (A,C)	8q24	CC+CA	11.4	11.9	1.86	0.68	5.10
rs6983267 (T,G)	8q24	GG+GT	80.7	81.0	0.86	0.34	2.17
rs1447295 (C,A)	8q24	AA+AC	25.0	23.8	0.88	0.40	1.93

Groups associated with elevated risk of prostate cancer in Table II.

^†

Living cases and those who died of other causes.

^‡

Cox proportional hazards model was used to estimate hazard ratios associated with each factor. The model was adjusted for age, Gleason score (2–6, 7=3+4, 7=4+3, 8–10), stage at diagnosis (local, regional, distant), PSA at diagnosis, and primary treatment.