Table 2.
Clinical and pathologic characteristics of DCIS according to patient age.
| Factor | Age | p-value | ||||
|---|---|---|---|---|---|---|
| Total (N=657) | <45 (N=111) | 45–54 (N=191) | 55–64 (N=160) | 65+ (N=195) | ||
| Presentation+ | ||||||
| Mammo abnormality | 530 (81) | 75 (68) | 157 (82) | 130 (81) | 168 (86) | .003 |
| Palpable mass | 122 (19) | 34 (31) | 32 (17) | 30 (19) | 26 (13) | |
| Other | 2 (<1) | 1 (1) | 1 (<1) | 0 (0) | 0 (0) | |
| Unknown | 3 (<1) | 1 (1) | 1 (<1) | 0 (0) | 1 (<1) | |
| Family history++ | ||||||
| No | 526 (80) | 93 (84) | 157 (82) | 126 (79) | 150 (77) | .65 |
| Yes | 113 (17) | 17 (15) | 31 (16) | 26 (16) | 39 (20) | |
| Unknown | 18 (3) | 1 (1) | 3 (2) | 8 (5) | 6 (3) | |
| DCIS nuclear grade# | ||||||
| Low | 68 (10) | 8 (7) | 21 (11) | 21 (13) | 18 (9) | .48 |
| Intermediate | 349 (53) | 65 (59) | 95 (50) | 78 (49) | 111 (57) | |
| High | 238 (36) | 38 (34) | 74 (39) | 60 (38) | 66 (34) | |
| Unknown | 2 (<1) | 0 (0) | 1 (<1) | 1 (<1) | 0 (0) | |
| DCIS highest nuclear grade | ||||||
| Low | 53 (8) | 5 (5) | 14 (7) | 19 (12) | 15 (7) | .17 |
| Intermediate | 333 (51) | 62 (56) | 90 (47) | 73 (46) | 108 (55) | |
| High | 269 (41) | 44 (40) | 86 (45) | 67 (42) | 72 (37) | |
| Unknown | 2 (<1) | 0 (0) | 1 (<1) | 1 (<1) | 0 (0) | |
| DCIS pattern# | ||||||
| Solid | 248 (38) | 44 (40) | 69 (36) | 60 (38) | 75 (38) | .74 |
| Cribriform | 228 (35) | 40 (36) | 71 (37) | 56 (35) | 61 (31) | |
| Micropapillary | 43 (7) | 10 (9) | 10 (5) | 9 (6) | 14 (7) | |
| Comedo | 73 (11) | 6 (5) | 25 (13) | 18 (12) | 24 (12) | |
| Papillary | 53 (8) | 10 (9) | 12 (6) | 13 (8) | 18 (9) | |
| Other: Clinging | 10 (15) | 1 (1) | 3 (2) | 3 (2) | 3 (2) | |
| Unknown | 2 (<1) | 0 (0) | 1 (<1) | 1 (<1) | 0 (0) | |
| Comedo necrosis | ||||||
| Absent | 272 (41) | 40 (36) | 85 (45) | 60 (38) | 87 (45) | .27 |
| Present | 383 (58) | 71 (64) | 105 (55) | 99 (62) | 108 (55) | |
| Unknown | 2 (<1) | 0 (0) | 1 (<1) | 1 (<1) | 0 (0) | |
| % of Ducts with Comedo necrosis | ||||||
| < 50% | 241 (37) | 49 (44) | 62 (32) | 62 (39) | 68 (35) | .67 |
| ≥ 50% | 136 (21) | 21 (19) | 40 (21) | 36 (23) | 39 (20) | |
| Unknown | 6 (1) | 1 (1) | 3 (2) | 1 (<1) | 1 (,1) | |
| Cancerization of lobules | ||||||
| Absent | 226 (34) | 26 (23) | 49 (26) | 54 (34) | 97 (50) | < .0001 |
| Present | 428 (65) | 85 (77) | 140 (73) | 105 (66) | 98 (50) | |
| Unknown | 3 (<1) | 0 (0) | 2 (1) | 1 (<1) | 0 (0) | |
| Stromal desmoplasia | ||||||
| Absent | 406 (62) | 71 (64) | 108 (57) | 90 (56) | 137 (70) | .02 |
| Present | 249 (38) | 40 (36) | 82 (43) | 69 (43) | 58 (30) | |
| Unknown | 2 (<1) | 0 (0) | 1 (<1) | 1 (<1) | 0 (0) | |
| Stromal inflammation# | ||||||
| Absent | 438 (67) | 77 (69) | 122 (64) | 104 (65) | 135 (69) | .67 |
| Present | 217 (33) | 34 (31) | 68 (36) | 55 (34) | 60 (31) | |
| Unknown | 2 (<1) | 0 (0) | 1 (<1) | 1 (<1) | 0 (0) | |
| ADH | ||||||
| Absent | 406 (62) | 72 (65) | 124 (65) | 92 (58) | 118 (61) | .49 |
| Present | 250 (38) | 39 (35) | 67 (35) | 67 (42) | 77 (39) | |
| Unknown | 1 (<1) | 0 (0) | 0 (0) | 1 (<1) | 0 (0) | |
| ALH/LCIS | ||||||
| Absent | 488 (74) | 91 (82) | 137 (72) | 120 (75) | 140 (72) | .18 |
| Present | 169 (26) | 20 (18) | 54 (28) | 40 (25) | 55 (28) | |
| Columnar cell change | ||||||
| Absent | 451 (69) | 74 (67) | 112 (59) | 113 (71) | 152 (78) | .0006 |
| Present | 206 (31) | 37 (33) | 79 (41) | 47 (29) | 43 (22) | |
| Extent of DCIS | ||||||
| Mean No. of LPF | 13.2 | 18.6 | 14.2 | 10.8 | 11.3 | .0006 |
| Median (range) | 7 (1–138) | 8.5 (1–138) | 8 (1–87) | 7 (1–89) | 7 (1–109) | |
| Mean No. of slides reviewed | 18.7 | 19.1 | 20.1 | 18.0 | 17.8 | .21 |
| Median (range) | 17 (1–117) | 17 (3–54) | 18 (3–85) | 16.5 (2–117) | 15 (1–69) | |
Numbers in parentheses are percentages unless otherwise indicated
+
Mammographic abnormality (screening, no symptoms); mass (or other symptoms); other (breast reduction, etc.).
++
History of breast cancer in 1st degree blood relative noted at or within 6 months of DCIS diagnosis.
#
Predominant or prominent.
Values adjusted for matching factors (health plan, age at diagnosis, year of diagnosis and follow-up time).