Table 3.
Biomarker profile and inferred molecular phenotype of DCIS according to patient age.
| Factor* | Age | p-value | ||||
|---|---|---|---|---|---|---|
| Total (N=554) | <45 (N=93) | 45–54 (N=157) | 55–64 (N=140) | 65+ (N=164) | ||
| ER | ||||||
| Positive | 474 (86) | 87 (94) | 129 (82) | 118 (84) | 140 (85) | .07 |
| Negative | 80 (14) | 6 (6) | 28 (18) | 22 (16) | 24 (15) | |
| PR | ||||||
| Positive | 413 (75) | 79 (85) | 118 (75) | 99 (71) | 117 (71) | .08 |
| Negative | 136 (25) | 14 (15) | 38 (24) | 39 (28) | 45 (27) | |
| Unknown | 5 (1) | 0 (0) | 1 (1) | 2 (1) | 2 (1) | |
| HER2 | ||||||
| 0 to 1+ | 340 (61) | 57 (61) | 97 (62) | 87 (62) | 99 (60) | .17 |
| 2+ | 120 (22) | 28 (30) | 28 (18) | 27 (19) | 37 (23) | |
| 3+ | 92 (17) | 8 (8) | 30 (19) | 26 (19) | 28 (17) | |
| Unknown | 2 (<1) | 0 (0) | 2 (1) | 0 (0) | 0 (0) | |
| Tumor Subtypes** | ||||||
| Luminal (ER/PR+, HER2+ or −) | 472 (85) | 87 (94) | 127 (81) | 118 (84) | 140 (85) | .30 |
| Triple negative/Basal like (ER−, PR−, HER2−) | 38 (7) | 4 (4) | 14 (9) | 9 (6) | 11 (7) | |
| HER2 type (ER−, PR−, HER2+) | 41 (7) | 2 (2) | 14 (9) | 12 (9) | 13 (8) | |
| Unknown | 3 (<1) | 0 (0) | 2 (1) | 1 (1) | 0 (0) | |
*
Restricted to those with known ER.
**
HER2 negative are 0 to 1+ and 2+; HER2 positive are 3+.
Values adjusted for matching factors (health plan, age at diagnosis, year of diagnosis and follow-up time).