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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Am J Surg Pathol. 2009 Dec;33(12):1802–1808. doi: 10.1097/pas.0b013e3181b7cb7a

Table 4.

Prior studies that have evaluated pathologic features of DCIS according to patient age.

Definition of young age, years (n) Other age groups evaluated, years (n) Pathologic features significantly more frequent in younger women
Vicini, 2000 (30) <45 (31) ≥45 (117)

  • Larger lesion size

  • Presence of central necrosis

  • Cancerization of lobules (COL) ≤5mm from the margin
Goldstein, 2000 (11) <45 (32) 45–59 (60)
>60 (85)

  • Larger lesion size

  • High grade

  • Presence of central necrosis

  • COL ≤5mm from the margin
Kerlikowske, 2003 (15) 40s (51) 50s (49)
60s (43)
70s (57)		 None
Rodrigues, 2003 (20) ≤42 (20) ≥60 (34) None
Bijker, 2006 (2) ≤40 (65) >40 (945)

  • Clinical symptoms as method of detection

  • Intermediate grade

  • Cribriform and solid/comedo architecture

  • Involved margins
Meijen, 2008 (16) ≤39 (9) ≥40 (201) None
Current study, 2009 <45 (111) 45–54 (191)
55–64 (160)
65+(195)

  • Non-mammographic method of detection

  • Larger lesion size

  • Presence of cancerization of lobules

  • Presence of stromal desmoplasia