Figure 7.

The apical domain regulates cell fate determinant localization and activity. (A) Aurora-A (AurA)-induced complex remodeling leads to the phosphorylation-mediated exclusion of the Lgl form and entry of Par-3 into the Par complex. This complex remodelling is associated with an alteration of the aPKC substrate specificity toward Numb and Miranda, which are hence excluded from the cortical domain occupied by aPKC. (B) The ratio of apical/basal determinants specifies cellular identity. Asymmetric neuroblast divisions can occur, although both daughter cells inherit cell fate determinants (green) that are inhibited by aPKC (red) in one daughter cell (DNA, blue).