Table 2.
Parameters for simulating the seven artificial datasets.
| Sample (in ascending order of age) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Dataset | Pattern | 1-10 | 11-20 | 21-30 | 31-40 | 41-50 | 51-60 | 61-70 | 71-80 |
| DE, 2 | C | 4, 2 | 4, 2 | 4, 2 | 4, 2 | 4, 2 | 4, 2 | 4, 2 | 4, 2 |
| L | 1, 2 | 2, 2 | 3, 2 | 4, 2 | 5, 2 | 6, 2 | 7, 2 | 8, 2 | |
| NL | 1, 2 | 2, 2 | 3, 2 | 4, 2 | 5, 2 | 4, 2 | 3, 2 | 1, 2 | |
| DE, 5 | C | 4, 5 | 4, 5 | 4, 5 | 4, 5 | 4, 5 | 4, 5 | 4, 5 | 4, 5 |
| L | 1, 5 | 2, 5 | 3, 5 | 4, 5 | 5, 5 | 6, 5 | 7, 5 | 8, 5 | |
| NL | 1, 5 | 2, 5 | 3, 5 | 4, 5 | 5, 5 | 4, 5 | 3, 5 | 1, 5 | |
| DE, 5+outliers | C | 4, 5 | 4, 5 | 4, 5 | 4, 5 | 4, 5 | 4, 5 | 4, 5 | 4, 5 |
| L | 1, 5 | 2, 5 | 3, 5 | 4, 5 | 5, 5 | 6, 5 | 7, 5 | 8, 5 | |
| NL | 1, 5 | 2, 5 | 3, 5 | 4, 5 | 5, 5 | 4, 5 | 3, 5 | 1, 5 | |
| DE, 9 | C | 4, 9 | 4, 9 | 4, 9 | 4, 9 | 4, 9 | 4, 9 | 4, 9 | 4, 9 |
| L | 1, 9 | 2, 9 | 3, 9 | 4, 9 | 5, 9 | 6, 9 | 7, 9 | 8, 9 | |
| NL | 1, 9 | 2, 9 | 3, 9 | 4, 9 | 5, 9 | 4, 9 | 3, 9 | 1, 9 | |
| DE, 9+outliers | C | 4, 9 | 4, 9 | 4, 9 | 4, 9 | 4, 9 | 4, 9 | 4, 9 | 4, 9 |
| L | 1, 9 | 2, 9 | 3, 9 | 4, 9 | 5, 9 | 6, 9 | 7, 9 | 8, 9 | |
| NL | 1, 9 | 2, 9 | 3, 9 | 4, 9 | 5, 9 | 4, 9 | 3, 9 | 1, 9 | |
| DV | C | 4, 3 | 4, 3 | 4, 3 | 4, 3 | 4, 3 | 4, 3 | 4, 3 | 4, 3 |
| L | 4, 1 | 4, 2 | 4, 3 | 4, 4 | 4, 5 | 4, 6 | 4, 7 | 4, 8 | |
| NL | 4, 1 | 4, 2 | 4, 3 | 4, 4 | 4, 5 | 4, 3 | 4, 2 | 4, 1 | |
| DV+outliers | C | 4, 3 | 4, 3 | 4, 3 | 4, 3 | 4, 3 | 4, 3 | 4, 3 | 4, 3 |
| L | 4, 1 | 4, 2 | 4, 3 | 4, 4 | 4, 5 | 4, 6 | 4, 7 | 4, 8 | |
| NL | 4, 1 | 4, 2 | 4, 3 | 4, 4 | 4, 5 | 4, 3 | 4, 2 | 4, 1 | |
Gene expression values can be simulated by drawing values from a normal distribution with mean μ and standard deviation σ. The choice of μ and σ depends on the age group of a sample and the type of pattern each gene is simulating. The complete list of μ and σ used to simulate the seven artificial microarray datasets are shown here, given as μ, σ pairs.