Table 4.
Cholesterol biosynthesis pathway. This table lists the proteins that are the constituents of the cholesterol biosynthesis pathway (Figure 5E). Column 1 gives the uniprot identifier, column 2 the short gene description, column 3 the gene symbol and column 4 highlights the features of this protein, including whether or not it is a HIV-1, siRNA or drug target.
| Uniprot id | Gene description | Gene Symbol | Properties |
|---|---|---|---|
| Q01581 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) | HMGCS1 | siRNA protein |
| Q03426 | mevalonate kinase | MVK | None |
| Q14534 | squalene epoxidase | SQLE | Known drug target |
| P48449 | lanosterol synthase (2 3-oxidosqualene-lanosterol cyclase) | LSS | Known drug target |
| Q15126 | phosphomevalonate kinase | PMVK | None |
| P53602 | mevalonate (diphospho) decarboxylase | MVD | None |
| O95749 | geranylgeranyl diphosphate synthase 1 | GGPS1 | None |
| P37268 | farnesyl-diphosphate farnesyltransferase 1 | FDFT1 | HIV-1 target according to predictions |