TABLE 5.

Total energy and amino acid efficiencies for the central residues of the BH3 peptides

Energies and absolute values of amino acid efficiencies are given in kcal·mol⁻¹.

Residue no.	BH3 peptides
	1G5J (Bad 25)a			2BZW (Bad 27)b			1PQ1 (Bim 33)b			1BXL (Bak 16)b			1ZY3 (Bid 20)b
	AAb	ΔGAA	Fc	AA	ΔGAA	F	AA	ΔGAA	F	AA	ΔGAA	F	AA	ΔGAA	F
8	Ala	−2.3	0.5	Ala	−2.6	0.5	Glu	1.6	0.2				Ile	−4.0	0.5
9	Gln	−0.4	0.0	Gln	−2.5	0.3	Ile	−2.3	0.3	Gly	−1.0	0.3	Lys	−3.5	0.4
10	Arg	1.8	0.2	Arg	−1.0	0.1	Trp	−0.7	0.1	Gln	−0.5	0.1	Asn	0.3	0.0
11	Tyr	−1.6	0.1	Tyr	−3.3	0.3	Ile	−3.2	0.4	Val	−1.1	0.2	Ile	−3.5	0.4
12	Gly	−1.8	0.5	Gly	−2.0	0.5	Ala	−2.7	0.5	Gly	0.0	0.0	Ala	−1.5	0.3
13	Arg	−1.3	0.1	Arg	−1.8	0.2	Gln	−0.7	0.1	Arg	0.8	0.1	Arg	−0.6	0.1
14	Glu	0.1	0.0	Glu	0.1	0.0	Glu	0.4	0.0	Gln	−2.0	0.2	His	0.1	0.0
15	Leu	−5.0	0.6	Leu	−4.7	0.6	Leu	−4.3	0.5	Leu	−5.8	0.7	Leu	−3.4	0.4
16	Arg	−0.1	0.0	Arg	−3.2	0.3	Arg	−0.6	0.1	Ala	−2.7	0.5	Ala	−2.0	0.4
17	Arg	−0.7	0.1	Arg	−0.7	0.1	Arg	−1.0	0.0	Ile	−0.8	0.1	Gln	−0.3	0.0
18	Met	−2.8	0.4	Met	−2.6	0.3	Ile	−2.9	0.4	Ile	−5.0	0.6	Val	−1.8	0.3
19	Ser	−1.1	0.1	Ser	−0.7	0.1	Gly	−1.9	0.5	Gly	−2.0	0.5	Gly	0.4	0.1
20	Asp	−1.1	0.1	Asp	−5.0	0.6	Asp	−4.8	0.5	Asp	−4.1	0.5	Asp	−6.0	0.8
21	Glu	−4.8	0.5	Glu	−1.4	0.2	Glu	−1.9	0.2	Asp	−2.0	0.3	Ser	−0.7	0.1
22	Phe	−5.5	0.5	Phe	−5.5	0.5	Phe	−6.2	0.6	Ile	−8.2	1.0	Met	−2.6	0.3
23	Val	−2.0	0.3	Val	−1.5	0.2	Asn	−3.4	0.5	Asn	−5.4	0.7	Asp	1.2	0.2
24	Asp	0.5	0.1	Asp	0.7	0.1	Ala	0.0	0.0	Arg	−3.4	0.3	Arg	−2.7	0.2
25	Ser	0.3	0.1	Ser	0.0	0.0	Tyr	−3.9	0.7				Ser	−4.7	0.8
26	Phe	−4.7	0.4	Phe	−2.8	0.3	Tyr	−6.3	0.5				Ile	−5.4	0.7

^a BH3 peptide and its amino acid length are shown.

^b AA means amino acid.

^c This is the absolute value of the amino acid efficiency.