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. 2009 Dec 14;4(12):e8284. doi: 10.1371/journal.pone.0008284

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Haÿ et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) MC3T3-E1 osteoblasts stably transfected with N-cadherin (N-Cad) display a 2-fold increase in N-cadherin expression compared to control cells (Flag) as shown by western blot analysis. (B, C) Decreased cell number and replication in N-Cad cells compared to Flag cells. (D, E) Decreased cell number and replication in primary calvarial osteoblasts isolated from N-cadherin transgenic mice (Tg) compared to osteoblasts from wild-type mice (WT). Means are +/− SD. Values that are significantly different are indicated (*, P<0.05 vs Flag or WT cells). (F) Histologial sections of tibias showing decreased cell proliferation in N-Cad Tg mice compared to WT mice, as revealed by Ki67 staining (black nuclei) in bone marrow stromal cells and mature osteoblasts (Ob, arrows) (x250).