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. Author manuscript; available in PMC: 2009 Dec 3.
Published in final edited form as: J Dermatol Sci. 2007 Nov 19;49(1):7–19. doi: 10.1016/j.jdermsci.2007.09.009

Table 2.

Mast cell-derived IL-10 limits epidermal necrosis associated with CHS to DNFB.

Mice with full thickness epidermal necrosis
Time after DNFB challenge 5 days 10 days
WBB6F1-Kit+/+ 0/19 0/5
WBB6F1-KitW/W-v 8/10* 2/3*
WT BMCMCs→KitW/W-v 0/16 0/3
Il10−/− BMCMCs→KitW/W-v 11/15* 2/3*

Values indicate numbers of mice whose ears exhibited full thickness epidermal necrosis, and, in some cases, ulcers as assessed by histology at 5 or 10 days after challenge with DNFB (mice with necrosis/total mice).

*

P < 0.05, wild type (Kit+/+) mice or WT (wild type) BMCMCs→KitW/W-v mice versus the corresponding mast cell-deficient KitW/W-v mice or Il10−/− BMCMCs→KitW/W-v mice. Data are from three experiments with similar results on day 5 (3–6 mice per group per experiment) or one experiment on day 10 (3–5 mice per group).

Reproduced, with the permission of the publisher, from reference [34].