Table 3.
Regression analysis in European samples for all SNPs in selected subtypes.
| Controls | DLBCL | FL | MZ/MALT | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| SNP | N | N | OR (95% CI) | p value | N | OR (95% CI) | p value | N | OR (95% CI) | p value |
| RAD50_IVS4(+19)G/A | ||||||||||
| G/G | 384 | 100 | 1 | 0.896 | 107 | 1 | 0.474 | 43 | 1 | - |
| G/A | 187 | 53 | 1.05 (0.72 - 1.54) | 0.799 | 55 | 1.08 (0.74 - 1.58) | 0.677 | 19 | 1.01 (0.57 - 1.80) | 0.975 |
| A/A | 27 | 7 | 0.96 (0.40 - 2.30) | 0.935 | 10 | 1.31 (0.61 - 2.81) | 0.492 | 3 | 1.03 (0.29 - 3.61) | 0.966 |
| G/A & A/A | 214 | 22 | 1.01 (0.58 - 1.76) | 0.967 | ||||||
| RAD50_IVS7(-38)C/T | ||||||||||
| C/C | 568 | 153 | 1 | - | 166 | 1 | - | 58 | 1 | - |
| C/T | 34 | 9 | 1.01 (0.47 - 2.17) | 0.983 | 6 | 0.63 (0.26 - 1.53) | 0.304 | 8 | 3.02 (1.28 - 7.14) | 0.012 |
| T/T | 1 | 0 | 0.00 (0.00 -) | 1.000 | 1 | 3.41 (0.21 - 56.13) | 0.391 | 1 | 24.77 (1.43 - 427.94) | 0.027 |
| C/T & T/T | 35 | 9 | 0.97 (0.45 - 2.08) | 0.941 | 7 | 0.71 (0.31 - 1.64) | 9 | 3.39 (1.48 - 7.75) | 0.004 | |
| RAD50_IVS22(+24)A/G | ||||||||||
| A/A | 546 | 137 | 1 | - | 150 | 1 | - | 59 | 1 | - |
| A/G | 54 | 25 | 1.77 (1.05 - 2.96) | 0.031 | 24 | 1.61 (0.96 - 2.71) | 0.073 | 7 | 1.30 (0.55 - 3.04) | 0.550 |
| G/G | 1 | 1 | 4.54 (0.26 - 78.43) | 0.298 | 0 | 0.00 (0.00 -) | 1.000 | 0 | 0.00 (0.00 -) | 1.000 |
| A/G & G/G | 55 | 26 | 1.81 (1.09 - 3.01) | 0.022 | 24 | 1.59 (0.94 - 2.67) | 0.081 | 7 | 1.29 (0.55 - 3.02) | 0.560 |
| RAD50_IVS22(+62)A/G | ||||||||||
| A/A | 601 | 161 | - | - | 174 | - | - | 67 | - | - |
| A/G | 2 | 2 | - | - | 0 | - | - | 0 | - | - |
| G/G | 0 | 0 | - | - | 0 | - | - | 0 | - | - |
| NBS1_5(-905)T/C | ||||||||||
| T/T | 266 | 76 | 1 | 0.465 | 87 | 1 | 0.847 | 28 | 1 | 0.816 |
| T/C | 267 | 72 | 0.95 (0.66 - 1.37) | 0.769 | 63 | 0.75 (0.51 - 1.08) | 0.119 | 43 | 1.12 (0.65 - 1.93) | 0.678 |
| C/C | 64 | 14 | 0.77 (0.41 - 1.46) | 0.423 | 24 | 1.20 (0.70 - 2.06) | 0.498 | 7 | 1.02 (0.42 - 2.48) | 0.964 |
| NBS1_5UTR_(-352)_del(AGTA) | ||||||||||
| AGTA/AGTA | 524 | 138 | 1 | - | 137 | 1 | - | 60 | 1 | - |
| AGTA/- | 58 | 16 | 1.06 (0.59 - 1.92) | 0.839 | 18 | 1.08 (0.61 - 1.92) | 0.785 | 2 | 0.30 (0.07 - 1.29) | 0.105 |
| -/- | 2 | 0 | 0.00 (0.00 -) | 0.999 | 3 | 5.57 (0.90 - 34.52) | 0.065 | 0 | 0.00 (0.00 -) | 0.999 |
| AGTA/- & -/- | 60 | 16 | 1.03 (0.57 - 1.85) | 0.929 | 21 | 1.23 (0.71 - 2.11) | 0.461 | 2 | - | - |
| NBS1_IVS3(+208)G/A | ||||||||||
| G/G | 241 | 66 | 1 | 0.672 | 84 | 1 | 0.466 | 26 | 1 | 0.818 |
| G/A | 277 | 76 | 1.00 (0.68 - 1.45) | 0.977 | 63 | 0.67 (0.46 - 0.97) | 0.033 | 30 | 0.97 (0.56 - 1.71) | 0.935 |
| A/A | 78 | 19 | 0.86 (0.48 - 1.52) | 0.596 | 27 | 1.04 (0.62 - 1.72) | 0.892 | 10 | 1.14 (0.52 - 2.51) | 0.744 |
| NBS1_3UTR(+273)G/A | ||||||||||
| G/G | 268 | 78 | 1 | 0.256 | 90 | 1 | 0.509 | 26 | 1 | 0.807 |
| G/A | 263 | 73 | 0.97 (0.68 - 1.40) | 0.885 | 54 | 0.65 (0.44 - 0.95) | 0.026 | 33 | 1.28 (0.74 - 2.23) | 0.381 |
| A/A | 63 | 11 | 0.60 (0.24 - 1.19) | 0.142 | 24 | 1.12 (0.66 - 1.91) | 0.669 | 6 | 0.89 (0.35 - 2.29) | 0.813 |
| NBS1_X2_(102)_G/A | ||||||||||
| G/G | 266 | 75 | 1 | 0.521 | 87 | 1 | 0.935 | 28 | 1 | 0.698 |
| G/A | 272 | 72 | 0.95 (0.66 - 1.37) | 0.782 | 62 | 0.72 (0.50 - 1.04) | 0.082 | 33 | 1.15 (0.67 - 1.97) | 0.615 |
| A/A | 59 | 13 | 0.79 (0.41 - 1.53) | 0.486 | 24 | 1.31 (0.76 - 2.25) | 0.326 | 7 | 1.09 (0.45 - 2.67) | 0.849 |
| NBS1_X5_(553)_G/C | ||||||||||
| G/G | 255 | 76 | 1 | 0.306 | 84 | 1 | 0.786 | 28 | 1 | 0.938 |
| G/C | 270 | 72 | 0.90 (0.62 - 1.30) | 0.572 | 62 | 0.73 (0.50 - 1.06) | 0.098 | 33 | 1.12 (0.65 - 1.92) | 0.688 |
| C/C | 57 | 12 | 0.70 (0.36 - 1.39) | 0.310 | 22 | 1.22 (0.70 - 2.13) | 0.486 | 6 | 0.92 (0.36 - 2.36) | 0.857 |
| NBS1_X13_(2016)_A/G | ||||||||||
| A/A | 247 | 74 | 1 | 0.204 | 83 | 1 | 0.634 | 27 | 1 | 0.897 |
| A/G | 265 | 70 | 0.89 (0.61 - 1.30) | 0.549 | 59 | 0.69 (0.47 - 1.01) | 0.055 | 33 | 1.13 (0.65 - 1.95) | 0.671 |
| G/G | 55 | 10 | 0.61 (0.29 - 1.26) | 0.180 | 21 | 1.20 (0.68 - 2.12) | 0.537 | 6 | 0.94 (0.36 - 2.43) | 0.902 |
| MRE11_5(-1703)A/G | ||||||||||
| A/A | 261 | 76 | 1 | 0.431 | 81 | 1 | 0.725 | 25 | 1 | 0.100 |
| A/G | 267 | 60 | 0.91 (0.63 - 1.32) | 0.629 | 69 | 0.84 (0.58 - 1.21) | 0.341 | 29 | 1.20 (0.68 - 2.13) | 0.527 |
| G/G | 66 | 15 | 0.79 (0.42 - 1.47) | 0.457 | 22 | 1.03 (0.59 - 1.78) | 0.919 | 13 | 1.95 (0.93 - 4.10) | 0.076 |
| MRE11_5(-1456)C/T | ||||||||||
| C/C | 582 | 153 | 1 | - | 165 | 1 | - | 67 | - | - |
| C/T | 21 | 9 | 1.76 (0.78 - 3.96) | 0.173 | 9 | 1.38 (0.61 - 3.09) | 0.441 | 1 | - | - |
| T/T | 1 | 1 | 4.32 (0.26 - 72.48) | 0.309 | 0 | 0.00 (0.00 -) | 0.100 | 0 | - | - |
| C/T & T/T | 22 | 10 | 1.87 (0.86 - 4.08) | 0.115 | 9 | 1.34 (0.60 - 2.99) | 0.481 | |||
| MRE11_IVS2(+28)G/A | ||||||||||
| G/G | 189 | 51 | 1 | 0.751 | 54 | 1 | 0.967 | 17 | 1 | 0.144 |
| G/A | 277 | 81 | 1.07 (0.72 - 1.59) | 0.753 | 85 | 1.10 (0.75 - 1.63) | 0.623 | 32 | 1.42 (0.75 - 2.66) | 0.279 |
| A/A | 124 | 30 | 0.90 (0.54 - 1.49) | 0.675 | 34 | 0.99 (0.61 - 1.61) | 0.959 | 18 | 1.69 (0.83 - 3.46) | 0.150 |
| MRE11_IVS9(-60)A/T | ||||||||||
| T/T | 270 | 82 | 1 | 0.419 | 77 | 1 | 0.866 | 27 | 1 | 0.625 |
| T/A | 255 | 61 | 0.75 (0.51 - 1.09) | 0.130 | 79 | 1.15 (0.80 - 1.66) | 0.453 | 29 | 1.19 (0.68 - 2.11) | 0.542 |
| A/A | 70 | 20 | 0.96 (0.55 - 1.68) | 0.877 | 17 | 0.82 (0.45 - 1.47) | 0.498 | 9 | 1.14 (0.51 - 2.58) | 0.752 |
| BLM_IVS7(+388)C/T | ||||||||||
| C/C | 517 | 140 | 1 | - | 148 | 1 | - | 62 | 1 | - |
| C/T | 78 | 22 | 1.04 (0.62 - 1.73) | 0.891 | 24 | 1.03 (0.63 - 1.70) | 0.908 | 6 | 0.62 (0.26 - 1.49) | 0.284 |
| T/T | 3 | 0 | 0.00 (0.00 -) | 0.999 | 1 | 0.96 (0.10 - 9.65) | 0.970 | 0 | 0.00 (0.00 -) | 0.999 |
| C/T & T/T | 81 | 22 | 1.01 (0.60 - 1.68) | 0.978 | 25 | 1.03 (0.623- 1.68) | 0.915 | 6 | 0.59 (0.25 - 1.43) | 0.244 |
| BLM_IVS7(+798)ins(T) | ||||||||||
| T/T | 528 | 145 | 1 | - | 156 | 1 | - | 62 | 1 | - |
| T/- | 69 | 17 | 0.89 (0.51 - 1.57) | 0.689 | 17 | 0.90 (0.51 - 1.58) | 0.702 | 5 | 0.71 (0.27 - 1.84) | 0.474 |
| -/- | 4 | 0 | 0.00 (0.00 -) | 0.999 | 1 | 1.09 (0.12 - 10.39) | 0.939 | 0 | 0.00 (0.00 -) | 0.999 |
| T/- & -/- | 73 | 17 | 0.84 (0.48 - 1.47) | 0.534 | 18 | 0.90 (0.52 - 1.58) | 0.722 | 5 | 0.67 (0.26 - 1.75) | 0.418 |
| BLM_IVS12(+7)T/C | ||||||||||
| T/T | 316 | 88 | 1 | 0.944 | 88 | 1 | 0.696 | 33 | 1 | 0.609 |
| T/C | 243 | 58 | 0.85 (0.58 - 1.23) | 0.389 | 68 | 0.99 (0.69 - 1.43) | 0.975 | 29 | 1.18 (0.69 - 2.02) | 0.546 |
| C/C | 45 | 15 | 1.23 (0.55 - 2.32) | 0.533 | 16 | 1.21 (0.65 - 2.26) | 0.554 | 5 | 1.12 (0.41 - 3.07) | 0.823 |
| BLM_IVS21(-60)_del(GAA) | ||||||||||
| GAA/GAA | 237 | 61 | 1 | 0.968 | 74 | 1 | 0.727 | 37 | 1 | 0.026 |
| GAA/- | 283 | 81 | 1.09 (0.75 - 1.60) | 0.640 | 75 | 0.87 (0.60 - 1.26) | 0.452 | 21 | 0.46(0.26 - 0.82) | 0.008 |
| -/- | 76 | 19 | 0.94 (0.53 - 1.69) | 0.840 | 24 | 0.98 (0.58 - 1.68) | 0.949 | 8 | 0.56 (0.24 - 1.27) | 0.162 |
OR = Odds Ratio, CI = Confidence Interval, DLBCL = Diffuse Large B-Cell Lymphoma, FL = Follicular Lymphoma, MZ/MALT = Marginal Zone lymphoma/Mucosa-Associated Lymphoma Tissue lymphoma.
If less than 5 samples were in a category, the analysis is not valid and marked by "-". Analyses were not done for subtypes that had fewer than 5 heterozygotes and minor homozygotes combined. Analysis is adjusted for adjusted for gender, ethnicity, age, and residence.
p-value for test for trend is shown in italic type.
p-values less than 0.05 are in bold.
All results are in Additional file 9.