Table 2.
Effect of pitavastatin on components of aortic plaque in wHHL rabits
| Plaque components | Control | Pitavastatin | Percent difference |
|---|---|---|---|
| α-SMA in the intima | |||
| Intimal area (mm2) | 8.47 ± 0.64 | 4.54 ± 0.62** | −46.4% |
| α-SMA positive area (mm2) | 0.68 ± 0.05 | 0.69 ± 0.08 | +1.5% |
| Percent area (%) | 8.45 ± 0.52 | 16.2 ± 0.94** | +91.7% |
| Collagen in the intima | |||
| Intimal area (mm2) | 9.54 ± 0.69 | 5.78 ± 0.88** | −39.4% |
| Collagen positive area (mm2) | 1.19 ± 0.15 | 1.28 ± 0.25 | +7.6% |
| Percent area (%) | 12.2 ± 1.2 | 20.3 ± 1.6** | +66.4% |
| Macrophage in the intima | |||
| Intimal area (mm2) | 9.13 ± 0.66 | 5.27 ± 0.79** | −42.3% |
| Macrophage positive area (mm2) | 2.95 ± 0.18 | 1.00 ± 0.16** | −66.1% |
| Percent area (%) | 33.5 ± 2.1 | 20.3 ± 2.5** | −39.4% |
Notes: N = 11. Mean ± Se.
**
P < 0.01 versus the control group.
Abbreviation: α-SMA, α-smooth muscle actin.
Modified from Suzuki et al.19