Fig. 1.

Dose-dependent effect of resveratrol on the secretory responses of catecholamines (CA) evoked by acetylcholine (upper) and high potassium (lower) from the isolated perfused rat adrenal glands. The CA secretion by a single injection of ACh (5.32×10^-3 M) and K⁺ (5.6×10^-2 M) in a volume of 0.05 ml was evoked at 15 min intervals during loading with 10, 30 and 100µM of resveratrol for 90 min as indicated by the arrow marks, respectively. The numbers in parentheses indicate the number of rat adrenal glands. Vertical bars on the columns represent the standard error of the mean (SEM). Ordinate: the amounts of CA secreted from the adrenal gland (% of control). Abscissa: collection time of perfusate (min). Statistical difference was obtained by comparing the corresponding control (CONTROL) with each concentration- treated group of resveratrol. ACh- and high K⁺-induced perfusates were collected for 4 minutes, respectively. ^**p<0.01. ns: not statistically significant.