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. Author manuscript; available in PMC: 2010 Dec 10.
Published in final edited form as: J Med Chem. 2009 Dec 10;52(23):7678–7688. doi: 10.1021/jm900694z

Figure 7.

Figure 7

Micrographs of hematoxylin/eosin stained kidney sections as a function of treatment as described in Figure 3. Tissue from control mice is healthy, exhibiting well-formed tubules, glomeruli, and cells. Treatment with 2.5 mg/kg Dox resulted in the appearance of a vacuolar-like damage (asterisks) and hyaline deposits in a subset of tubules (triangle). Neither prodrug treatment resulted in visible cellular damage, although a dose-dependent congestion of tubules with hyaline deposits (triangles) was evident. Additionally, the higher dose of PPD induced a thickening of Bowman's capsule in a small population of glomeruli, as shown on the right. The bar indicates 200 µm.