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. Author manuscript; available in PMC: 2010 Dec 10.
Published in final edited form as: J Med Chem. 2009 Dec 10;52(23):7678–7688. doi: 10.1021/jm900694z

Figure 8.

Figure 8

Micrographs of hematoxylin/eosin stained ileum sections as a function of treatment as described in Figure 3. Ileum tissue from control mice shows a well-formed villi structure and normal goblet cells. Neither treatment with Dox nor either dosage of pentyl PABC-Doxaz resulted in visible damage. This is in contrast to the literature reports in which treatment with irinotecan resulted in significant damage to the ileum, such as loss of villi and severe disorganization of the tissue, as well as cellular vacuolar damage. The bar indicates 150 µm.