. Author manuscript; available in PMC: 2010 Dec 10.

Published in final edited form as: J Med Chem. 2009 Dec 10;52(23):7458–7462. doi: 10.1021/jm9005934

Table 1.

Antimalarial Efficacy Using a Single Oral Dose of Trioxane Combined with Mefloquine Hydrochloride in Plasmodium berghei-infected Mice

	Oral Dose
Trioxane	Trioxane (mg/kg)	Mefloquine Hydrochloride (mg/kg)	Average survival (days) after infection	% Suppression of parasitemia (on day 3 post infection)
2b	6,8	20	19.8 (16,17,21,22,23)^a	99.8
2b	13	13	19.6 (16,17,21,22,22)^a	99.7
3	6.8	20	27.4 (22,25,30,30,30)^a	99.5
3	13	13	24.6 (17,21,25,30,30)^a	99.9
4a	6.8	20	27.8 (22,27,30,30,30)^a	99.9
4a	13	13	26.4 (21,23,26,30,30)^a	99.6
4b	6.8	20	30	99.0
4b	13	13	30	99.6
4b	72	0	24.4 (21,23,24,27,27)^a	99.0

Controls
vehicle (no drug)	0	0	6.4 (6,6,6,7,7)^a	0
2c	30	0	7.6^b	-^c
9	30	0	10.7^b	99.95^b
Mefloquine	0	20	17.6 (16,16,17,19,20)^a	99.6

Actual mouse survival until day.

Data from supporting information in ref. 13 using a single oral dose of 30 mg/kg.

Dash indicates “not measured”.