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. Author manuscript; available in PMC: 2010 Dec 10.
Published in final edited form as: J Med Chem. 2009 Dec 10;52(23):7380–7388. doi: 10.1021/jm900256f

Figure 2.

Figure 2

Schematic illustration of the polyamide cores and tail groups employed. A) At left are given the HRE match (1-11) and HRE mismatch (12-22) cores employed in U251 and LNCaP cells, and on the right the ARE match (23-33) and ARE mismatch (34-44) cores employed in LNCaP cells. Below the chemical structure is a schematic “ball-and-stick” shorthand representation of each core, in which pyrrole (Py) is symbolized by an open circle, imidazole (Im) by a filled circle, and chlorothiophene cap by an open square. B) The chemical structures of the tail groups “R” for compounds 1-44 are shown. Structures 45-48 are the “core-less” oxime-linked control compounds.