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. Author manuscript; available in PMC: 2010 Dec 10.
Published in final edited form as: J Med Chem. 2009 Dec 10;52(23):7380–7388. doi: 10.1021/jm900256f

Figure 3.

Figure 3

Quantitative real-time RT-PCR data showing the effect of HRE-targeted match compounds 1-4, 6-8 and their mismatch congeners 12-15, 17-19 on DFO-induced VEGF expression in cultured cells. Induced and uniduced control conditions are indicated by black bars, match core compounds by light grey bars, and mismatch core compounds by dark grey bars. Uninduced and induced control compounds without DMSO are on the left, and with 0.1% DMSO on the right. Errors shown are the fractional standard deviation. A) Expression of VEGF in cultured U251 cells under DFO-induced hypoxic conditions of match core control compounds 1-4 and mismatch core control compounds 12-15 at 1 μM concentration. Cells were treated with match compounds 6-8 and respective mismatch compounds 17-19 as 1, 0.2 and 0.02 μM cell culture media solutions. B) Expression of VEGF in cultured LNCaP cells under DFO-induced hypoxic conditions of match core control compounds 1-4 and mismatch core control compounds 12-15 at 10 μM. Cells were treated with match compounds 6-8 and respective mismatch compounds 17-19 as 10, 2 and 0.2 μM cell culture media solutions.