Table 2. Unadjusted clinical and financial outcomesa of 150 patients with methicillin-resistant Staphylococcus aureus surgical site infections (SSI) compared with 231 uninfected controls and 128 patients with methicillin-susceptible S. aureus SSI.
| MRSA SSI N = 150 n (%) | Uninfected Controls N = 231 n (%) | Unadjusted Odds Ratio [95% CI]; p-value | MSSA SSI N = 128 n (%) | Unadjusted Odds Ratio [95% CI]; p-value | |
| Died during admission | 5 (3.5) | 2 (0.9) | 4.69 [0.88–25.1]; 0.08 | 1 (0.8) | 4.31 [0.50–37.4]; 0.15 |
| Discharged tob: | <0.0001 | ||||
| Home | 90 (65.7) | 175 (78.5) | 0.33 [0.17–0.63]; 0.0005 | 92 (78.0) | 0.54 [0.31–0.95]; 0.03 |
| Facility | 47 (34.3) | 48 (21.5) | 3.06 [1.59–5.84]; 0.0005 | 26 (22.0) | 2.05 [1.16–3.62]; 0.01 |
| Outcomes within 90-days of procedure | |||||
| Readmitted within 90 days within of procedure b | 110 (77.5) | 23 (10.2) | 30.2 [16.8–54.1]; <0.0001 | 108 (87.1) | 0.51 [0.26–0.98]; 0.04 |
| Dead within 90 days of procedure | 25 (16.7) | 7 (3.0) | 7.20 [2.86–18.1]; <0.0001 | 9 (7.0) | 2.64 [1.19–5.90]; 0.01 |
| Total post-procedure length of hospitalization (days) – median (IQR) | 21 (10–32) | 5 (3–7) | <0.0001 | 15 (7–22) | 0.003 |
| Hospital charges – median (IQR)c | 79,029 (38,113–127,846) | 38,735 (17,753–60,627) | <0.0001 | 55,667 (22,201–86,757) | 0.001 |
a
P values calculated using Student t test or Wilcoxon rank sum test for continuous variables. P-values, odds ratios, and 95% confidence intervals for categorical variables were calculated using the Cochran-Mantel-Haenszel test (MRSA SSI v. matched-uninfected controls) and the Fisher exact test or chi-square (MRSA SSI v MSSA SSI). All percentages were calculated using denominators that excluded missing data.
b
Denominator includes patients who survived their index admissions.
c
Financial data were available for 144 cases (96%), 202 (87%) uninfected controls, and 127 (99%) MSSA SSI controls.