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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: Arthritis Rheum. 2009 Nov;60(11):3303–3313. doi: 10.1002/art.24882

Figure 2.

Figure 2

Differential qPCR expression of IL1B (A) and TNFA (B). Articular cartilage was obtained from either #NOF patients or OA patients. The surface zones were removed and analyzed separately from the deep zones. Results are shown for individual patients, arranged in age order. For each gene, #NOF and OA samples were analyzed in the same assay. Low levels of IL1B in the superficial zone of #NOF patients contrasted the 100–1000 fold increased expression in the surface zone of OA cartilage. With one exception (72 year old male), expression increased with age. There was no expression of IL1B in the deep zones of #NOF (one exception) or OA cartilage. By contrast, TNFA was expressed in the control chondrocytes located in the deep zone of #NOF patients and expression did not increase significantly in surface-zone OA chondrocytes.

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