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. 2009 Dec 14;4(12):e8312. doi: 10.1371/journal.pone.0008312

Figure 7. Effect of caveolar disruption and I Cl,swell inhibition on the contractile response to hyposmotic swelling.

Figure 7

Field-stimulated myocytes were exposed to 0.64T hypotonic solution for 10 min and the change in contractility (expressed as a % of resting cell length) measured. The negative inotropic response recorded at 6 and 10 min in control cells was enhanced in cells in which caveolae were disrupted with MBCD, and reversed in cells in which I Cl,swell was inhibited with 50 µM DIDS. * P<0.05 vs time-paired control (ANOVA; n = 19–21 cells).