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. Author manuscript; available in PMC: 2010 Nov 13.
Published in final edited form as: Mol Cell. 2009 Nov 13;36(3):405–416. doi: 10.1016/j.molcel.2009.10.020

Figure 7. Models of AR Target Gene Regulation by HOXB13.

Figure 7

(A) HOXB13 is a licensing factor for AR and AR coregulators (collaborative model). HOXB13 is required for robust recruitment of AR coregulators (TMPRSS2, NKX3.1) and in some instances AR (TMPRSS2) to AREs. The DNA binding function of HOXB13 is required for this activity.

(B) Activation function of HOXB13 (tether model). AR interacts directly with HOXB13 to activate target genes containing HOXB13 binding sites (ORM1). The DNA binding function of HOXB13 is required for AR activity.

(C) Repressor function of HOXB13. HOXB13 interacts with the AR DNA binding domain weakening the association of AR with chromatin. The DNA binding activity of HOXB13 is not required for repression.