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. Author manuscript; available in PMC: 2009 Dec 4.
Published in final edited form as: Cell. 2008 Oct 31;135(3):437–448. doi: 10.1016/j.cell.2008.08.041

Figure 2. Nf1+/− Bone Marrow Is Necessary for Plexiform Neurofibroma Formation in Krox20;Nf1flox/flox and Krox20;Nf1flox/− Mice.

Figure 2

(A) Previously irradiated Krox20;Nf1flox/flox and Krox20;Nf1flox/− mice transplanted with Nf1+/− or WT bone marrow were followed until 1 year of age. A Kaplan-Meier plot of percent survival (y axis) as a function of time (x axis) is shown. The genotypes are indicated. Comparisons of Krox20;Nf1flox/flox+ Nf1+/− BM (dashed line) versus Krox20;Nf1flox/flox+ WT BM (open squares) (p < 0.002); Krox20;Nf1flox/flox+ Nf1+/− BM (dashed line) versus Krox20;Nf1flox/− (open circles) (no significant difference). Krox20;Nf1flox/− (open circles) versus Krox20;Nf1flox/− + WT bone marrow (closed squares) (p < 0.0002).

(B) Photographs of Krox20;Nf1flox/flox mice transplanted with WT BM (1) or Nf1+/− BM (2 and 3). Arrowheads identify limbs with motor paralysis.

(C) Dissections of dorsal root ganglia and peripheral nerves of Krox20;Nf1flox/flox mice transplanted with WT or Nf1+/− bone marrow. Arrowheads identify tumors in dorsal root ganglia and proximal peripheral nerves.