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Concentration dependent inhibition of hLigI by small molecule inhibitors of hLigI identified by CADD. Left: Radioactively labeled nicked DNA substrate (0.5 pmol) and hLig1 (0.02 pmol) were incubated with varying concentrations of the indicated compounds. After agarose gel electrophoresis, ligation was detected and quantitated by phosphorimaging. The results of three independent experiments are shown graphically. Right: The IC50 values of the hLigI inhibitors are shown.
