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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Biochim Biophys Acta. 2008 Aug 7;1793(1):212–218. doi: 10.1016/j.bbamcr.2008.07.024

Fig. 1.

Fig. 1

The cardiolipin (CL) biosynthetic pathway: PGS1 encodes phosphatidylglycerol phosphate (PGP) synthase, which converts glycerol-3-phosphate (G-3-P) and CDP-diacylglycerol (CDP-DAG) to PGP. PGP is dephosphorylated to phosphatidylglycerol (PG) by PGP phosphatase. CRD1 encodes CL synthase, which converts CDP-DAG and phosphatidylglycerol (PG) to CL. In the proposed remodeling pathway, CL is deacylated to monolysocardiolipin (MLCL) by a phospholipase that has not been identified. MLCL is then reacylated to mature CL by Taz1p.