TABLE 1.

Liver lipid metabolites from Acsl1^L−/− and Acsl1^Flox/Flox mice fed a high fat or a control diet for 14–18 weeks

Samples were obtained after a 4-h fast. Data represent means ± S.E. The number of animals in each group is indicated in parentheses. KO, knock-out.

Total liver lipid metabolites	10% fat diet (control)		45% fat diet (high fat)
	Control (n = 10)	KO (n = 10)	Control (n = 10)	KO (n = 10)
Acyl-CoA (nmol/g liver)	30.1 ± 0.5	19.4 ± 0.4a	40.2 ± 0.9b	30.4 ± 0.6a,b
Lysophosphatidic acid (nmol/g liver)	2.69 + 0.14	2.19 ± 0.32	2.52 ± 0.24	3.82 ± 0.44c
Diacylglycerol (nmol/g liver)	949 ± 88	863 ± 98	957 ± 147	966 ± 123

^a p < 0.01 compared with control mice fed the same diet (two-way ANOVA).

^b p < 0.01 compared with 10% fat control diet in the same genotype (two-way ANOVA).

^c p < 0.05 compared with control mice (Student's t test).