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. 2009 Aug 11;284(41):27989–27997. doi: 10.1074/jbc.M109.016337

FIGURE 1.

FIGURE 1.

The invariant Glu and Arg residues are not conserved in the EAG family of K+ channels. Amino acid sequence alignment of the CNBD of the EAG family of K+ channels and other cyclic nucleotide-binding proteins. Identical residues are red on yellow background, conserved residues are blue on cyan background, similar residues are black on green background, and weakly similar residues are in green. The α-helices (red rectangles) and β-sheets (blue arrows) represent structural motifs from the crystal structure of the CNBD of mHCN2 channels (31). The six invariant residues are indicated by black arrows. The GenInfo identifier numbers are: mEAG1, 487740; rEAG1, 557265; dEAG, 24642070; hERG1, 103488986; mELK2, 187954689; mHCN2, 148699724; bCNGA1, 231739; MlotiK1, 81779664; bPKAIαB, 145559486; CAP, 168751822.