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Cyclic nucleotides do not modulate currents from mEAG1 and hERG1 channels. Currents and conductance-voltage relations for mHCN2 (A), mEAG1 (B), and hERG1-S631A (C) channels recorded in the inside-out patch configuration with cAMP (red), cGMP (green), and without the cyclic nucleotides (black). cAMP and cGMP were applied at 1 mm to the mHCN2 channels and 10 mm to mEAG1 and hERG1-S631A channels. The conductance-voltage relations were obtained from tail currents.
