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. 2009 Aug 7;284(41):28430–28441. doi: 10.1074/jbc.M109.031419

FIGURE 9.

FIGURE 9.

Structural models of PPCA-NEU1 heterodimers. A, structural model of NEU1 based on the crystal structure of M. viridifaciens sialidase. Peptides that showed positive binding to PPCA and/or NEU1 in the SPR-peptide screens are indicated in blue or red. B, a portion of each peptide is exposed to the surface, indicating that they are potentially in position to bind PPCA or NEU1. The peptides form two attachment bands on the surface; peptides 33, 34, 42, 48, and 70 (blue) form one band, and peptides 13 and 19 (red) form the other. C, structural model 1 of the PPCA-NEU1 heterodimer; NEU1 peptides 33, 34, and 42 (blue) interact with the PPCA excision peptide, and NEU1 peptide 48 (blue) interacts with the PPCA peptide 65 (red). D, structural model 2 of the PPCA-NEU1 heterodimer; NEU1 peptides 13 (red) and 70 (blue) interact with the PPCA peptide 74 (red) and the PPCA residue Pro-451.